Drug Safety & Pharmacovigilance

Aroylhydrazones can act as neutral, monoanionic or dianionic ONO tridentate ligands [1]. The coordination abilities of aromatic hydrazones derived from nicotinic acid hydrazide and differently substituted 2-hydroxybenzaldehydes towards Fe3+ and Ga3+ will be discussed. Different techniques, like UV-Vis, vibrational spectroscopy and mass spectrometry were used for structural investigation of the complexes in solution and in the solid state. In this work, the ESI MS and MS/MS spectra, including fragmentation pathways of Fe(III) and Ga(III) complexes with aroylhydrazones are presented.