Pharmaceutics and Drug Safety

The BBB for drug delivery

The brain is a very delicate and sensitive neuronal organ system that needs a constant supply of fuels, gases, and nutrients to maintain homeostasis and other important activities. Delivering drugs to the brain has been shown to be particularly difficult because of the blood-brain barrier (BBB). Only small molecules can pass through the BBB in a healthy brain, acting as a diffusion barrier to stop the majority of substances from entering the brain from the bloodstream. In the next 20 years, global drug development for brain diseases will need to significantly increase due to the rising numbers of seniors and patients with CNS issues. However, compared to other therapeutic areas, brain disease drug development has the lowest success rates.

• Nanoparticle Delivery Throughout The BBB
• Pharmacological Delivery to the Brain
• In states of disease, the blood-brain barrier
• BBB Models: New Approaches